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Review
. 1994 Mar 29;91(7):2428-9.
doi: 10.1073/pnas.91.7.2428.

Evolution of drug-resistant tuberculosis: a tale of two species

M D Iseman  1
Affiliations
Review

Evolution of drug-resistant tuberculosis: a tale of two species

M D Iseman. Proc Natl Acad Sci U S A. .

Abstract

The history of the disease tuberculosis is briefly discussed. Now human societal failures have potentiated the evolution of drug-resistant strains of the tubercle bacillus in the United States and around the world. Until recently, this evolutionary change largely posed a threat to the health and survival of the individual in whom inadequate therapy promoted the drug resistance. However, the human immunodeficiency virus epidemic threatens to promote wholesale transmission of multidrug-resistant tuberculosis with the potential for immense morbidity and mortality. Reinforced treatment and control programs for tuberculosis are vital.

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