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. 1994 Mar 29;91(7):2853-7.
doi: 10.1073/pnas.91.7.2853.

Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms

R H Farkas  1 , S Nakajima, Y Nakajima
Affiliations

Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms

R H Farkas et al. Proc Natl Acad Sci U S A. .

Abstract

The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.

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