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Review
. 1994 Jan 29;343(1304):225-46.
doi: 10.1098/rstb.1994.0023.

The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation

J R Vane  1
Affiliations
Review

The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation

J R Vane. Philos Trans R Soc Lond B Biol Sci. .

Abstract

The vascular endothelium plays a vital role in the control of the circulation. It metabolizes various vasoactive substances, coverts angiotensin I to angiotensin II and secretes the potent vasodilators prostacyclin and EDRF (NO) and the vasoconstrictor peptide endothelin-1. The balance between these mediators determines the responses of the cardiovascular system in diseases such as hypertension, atherosclerosis and myocardial infarction.

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