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Clinical Trial
. 1993 Jul-Sep;26(3):157-62.
doi: 10.1590/s0037-86821993000300005.

[Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia]

[Article in Portuguese]
J B Santos  1 , A Prata, E Wanssa
Affiliations
Clinical Trial

[Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia]

[Article in Portuguese]
J B Santos et al. Rev Soc Bras Med Trop. 1993 Jul-Sep.

Abstract

In a randomised double-blind study 122 volunteers living in an endemic malarious area in Amazonian Rondônia state were divided into 4 groups to study malaria suppression. . The first group received 500 mg of mefloquine every month, group II 250 mg every two weeks, group III a tablet of Fansidar (500 mg sulphadoxine + 25mg pyrimethamine) a week and group IV placebo. Acute attacks of malaria occurred in one individual in group I, 2 subject in group II, and 6 individuals in groups III and IV. Protection with mefloquine was significant compared with the placebo group. Both treatment regimens with mefloquine were effective suppressants in an area of high prevalence of drug multiresistant Plasmodium falciparum transmission.

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