Review
Etiology and pathophysiology of preeclampsia
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- PMID: 8147189
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Review
Etiology and pathophysiology of preeclampsia
Zentralbl Gynakol.
1994.
Abstract
The possible involvement of genetic and immune mechanisms in the etiology of preeclampsia has attracted increasing attention. Preeclampsia is characterized by a generalized disturbance in endothelial physiology, and not merely by an isolated defect in vascular prostacyclin synthesis. The increased production of oxygen free radicals and/or elastase by activated lymphoid cells in the pregnant decidua, a mainly lymphoid tissue, may be the link between the hypothetical immunologic mechanisms and the endothelial injury occurring in preeclampsia.
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