Review
doi: 10.1007/BF02087437.
Crohn's disease and cystic fibrosis
Affiliations
- PMID: 8149854
- DOI: 10.1007/BF02087437
Item in Clipboard
Review
Crohn's disease and cystic fibrosis
Dig Dis Sci.
1994 Apr.
Abstract
Advances in investigative techniques have led to increasing reports of Crohn's disease in CF patients. A retrospective review of the literature on IBD in CF showed findings characterized by ileocolitis with fistula formation; 83% required surgery. A prospective survey of 11,321 CF patients attending 49 CF centers revealed 28 with IBD (25 Crohn's, three ulcerative colitis), ages 4-20 years, mean 15.6 years. The prevalence rate of IBD (247/10(5)) was 7x controls and was accounted for by Crohn's disease (221/10(5)) which was 17x controls. The mechanisms that predispose CF patients to Crohn's disease are discussed.
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