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. 1994 May;68(5):3374-9.
doi: 10.1128/JVI.68.5.3374-3379.1994.

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

T Yamada  1 , S Yamaoka, T Goto, M Nakai, Y Tsujimoto, M Hatanaka
Affiliations

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

T Yamada et al. J Virol. 1994 May.

Abstract

The Tax protein of human T-cell leukemia virus type I activates transcription of cellular and viral genes and can immortalize primary T lymphocytes. We have previously reported that the Tax protein transforms Rat-1 cells. Here we show that Tax-transformed Rat-1 cells detach from plates to undergo apoptotic cell death by serum deprivation. These cells exhibit DNA fragmentation into oligonucleosomal fragments and chromatin condensation. Constitutive expression of a proto-oncogene, bcl-2, effectively blocks Tax-mediated apoptosis caused by serum deprivation without affecting the levels of Tax expression and the transformed phenotype of the cells.

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