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. 1994 Apr 21;368(6473):703-10.
doi: 10.1038/368703a0.

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

Y Kurihara  1 , H Kurihara, H Suzuki, T Kodama, K Maemura, R Nagai, H Oda, T Kuwaki, W H Cao, N Kamada, et al.
Affiliations

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

Y Kurihara et al. Nature. .

Abstract

The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

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