Lupus anticoagulant activity of some antiphospholipid antibodies against phospholipid bound beta 2 glycoprotein I
- PMID: 8157757
- PMCID: PMC501399
- DOI: 10.1136/jcp.46.7.665
Lupus anticoagulant activity of some antiphospholipid antibodies against phospholipid bound beta 2 glycoprotein I
Erratum in
- J Clin Pathol 1993 Oct;46(10):976
Abstract
Aims: To determine whether beta 2 glycoprotein I (beta 2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant activity.
Methods: Six anticardiolipin antibodies were affinity purified from patients with these antibodies and lupus anticoagulant activity in their plasma.
Results: The anticardiolipin antibodies bound only to anionic phospholipids in the presence of beta 2GPI and bound to beta 2GPI in the absence of phospholipids. Four out of six had lupus anticoagulant activity in the dilute Russell viper venom time test.
Conclusions: The results show that some beta 2GPI dependent aCL are lupus anticoagulants. It is unclear why only some should have lupus anticoagulant activity while others do not.
Similar articles
-
IgG reactivity to phospholipid-bound beta(2)-glycoprotein I is the main determinant of the fraction of lupus anticoagulant activity quenched by addition of hexagonal (II) phase phospholipid in patients with the clinical suspicion of antiphospholipid-antibody syndrome.Haematologica. 1999 Sep;84(9):829-38. Haematologica. 1999. PMID: 10477458
-
The role of beta 2-glycoprotein I-dependent lupus anticoagulants in the pathogenesis of the antiphospholipid syndrome.Verh K Acad Geneeskd Belg. 2000;62(5):353-72. Verh K Acad Geneeskd Belg. 2000. PMID: 11144685 Review.
-
Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies.Blood. 1995 Jul 15;86(2):617-23. Blood. 1995. PMID: 7605991
-
Some 'antiphospholipid antibodies' bind to beta 2-glycoprotein I in the absence of phospholipid.Br J Haematol. 1992 Nov;82(3):571-4. doi: 10.1111/j.1365-2141.1992.tb06469.x. Br J Haematol. 1992. PMID: 1486037
-
[Clinical significance of antiphospholipid antibodies].Rinsho Byori. 1998 Apr;46(4):297-302. Rinsho Byori. 1998. PMID: 9594618 Review. Japanese.
Cited by
-
Heterogeneity of antiphospholipid antibodies and their cofactors.Clin Rev Allergy Immunol. 1995 Spring;13(1):101-6. doi: 10.1007/BF02772253. Clin Rev Allergy Immunol. 1995. PMID: 7648344 Review. No abstract available.
-
Phospholipid binding specificities and idiotype expression of hybridoma derived monoclonal autoantibodies from splenic cells of patients with systemic lupus erythematosus.Ann Rheum Dis. 1995 Jun;54(6):471-6. doi: 10.1136/ard.54.6.471. Ann Rheum Dis. 1995. PMID: 7632089 Free PMC article.
-
Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes.Clin Exp Immunol. 1994 Aug;97(2):175-80. doi: 10.1111/j.1365-2249.1994.tb06064.x. Clin Exp Immunol. 1994. PMID: 8050163 Free PMC article.
-
Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro.J Clin Pathol. 1993 Oct;46(10):908-11. doi: 10.1136/jcp.46.10.908. J Clin Pathol. 1993. PMID: 8227406 Free PMC article.
-
Antigenic specificities of "antiphospholipid" autoantibodies.Springer Semin Immunopathol. 1994;16(2-3):211-22. doi: 10.1007/BF00197518. Springer Semin Immunopathol. 1994. PMID: 7536353 Review. No abstract available.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
