[Leukocyte adhesion deficiency: its clinical and molecular analyses]

Abstract

Leucocyte adhesion deficiency is an immunodeficiency disease of autosomal recessive inheritance characterized by recurrent bacterial skin infections, impired pus formation and delayed wound healing. Leukocytes, including granulocytes and lymphocytes, from the LAD show defect in adhesion molecules of beta 2 integrin, LFA-1, Mac-1 and p150, 95, on its leukocyte membrane surface. This paper is a review article describing clinical features, leukocyte functions and molecular basis for the defective expression of the beta 2 integrin molecules in the LAD.