Review
Influencing the influenza virus: genetic analysis and engineering of the negative-sense RNA genome
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- PMID: 8162350
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Review
Influencing the influenza virus: genetic analysis and engineering of the negative-sense RNA genome
Infect Agents Dis.
1993 Feb.
Abstract
The genome of influenza virus has become amenable to genetic analysis as a result of newly developed methods for reconstitution of the ribonucleoprotein (RNP) complex. This allows a dissection of the regulatory signals and promoters required for transcription and replication of the viral genome. The ability to rescue chimeric viruses in vivo after transfection opens up a way to engineer viruses suitable for human immunization and carrying desirable antigenic determinants.
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