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. 1994;66(4):274-6.
doi: 10.1159/000133711.

ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22

R Gaedigk  1 , A M Duncan, I Miyazaki, B H Robinson, H M Dosch
Affiliations

ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22

R Gaedigk et al. Cytogenet Cell Genet. 1994.

Abstract

The development of type 1 (insulin dependent) diabetes mellitus (IDDM) requires a genetically susceptible host and exposure, early in life, to environmental trigger molecules that induce diabetic autoimmunity to insulin producing islet cells. We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22.

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