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. 1994 May 1;179(5):1653-58.
doi: 10.1084/jem.179.5.1653.

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease

J L Telford  1 , P Ghiara, M Dell'Orco, M Comanducci, D Burroni, M Bugnoli, M F Tecce, S Censini, A Covacci, Z Xiang, et al.
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Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease

J L Telford et al. J Exp Med. .

Abstract

The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. Cloning of the H. pylori cytotoxin gene shows that the protein is synthesized as a 140-kD precursor that is processed to a 94-kD fully active toxin. Oral administration to mice of the purified 94-kD protein caused ulceration and gastric lesions that bear some similarities to the pathology observed in humans. The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines.

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