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Case Reports
. 1993 Sep;17(3):253-60.
doi: 10.1007/BF01049980.

Intracranial arterial occlusion associated with high-activity iodine-125 brachytherapy for glioblastoma

M Bernstein  1 , M Lumley, G Davidson, N Laperriere, P Leung
Affiliations
Case Reports

Intracranial arterial occlusion associated with high-activity iodine-125 brachytherapy for glioblastoma

M Bernstein et al. J Neurooncol. 1993 Sep.

Abstract

We describe two patients who developed devastating strokes due to intracranial arterial occlusion 15 weeks and 97 weeks following high dose stereotactic iodine-125 brachytherapy for glioblastoma multiforme. In both cases the occlusion was within the implant volume at points receiving 110-281 Gy and there was no other evidence of significant atherosclerosis in the patients. We therefore conclude that these complications were a direct result of the brachytherapy. The phenomenon of radiation-induced occlusion of large cerebral arteries is reviewed.

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