doi: 10.1016/0009-2797(76)90007-7.
Effects of selected water toxicants on the in vitro activity of fish carbonic anhydrase
- PMID: 816475
- DOI: 10.1016/0009-2797(76)90007-7
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Effects of selected water toxicants on the in vitro activity of fish carbonic anhydrase
Chem Biol Interact.
1976 May.
Abstract
Carbonic anhydrase (CA, carbonate hydro-lyase EC 4.2.1.1) from lysed red blood cells of the channel catfish (Ictalurus punctatus) was studied to determine physico-chemical kinetic properties and relative sensitivity to 56 chemicals of significance in water quality research. In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds. Dose--response curves were qualitatively similar in most cases.
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