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. 1994 Apr;9(2):129-37.

Synthesis and biological activity of 3'-deamino-3'-haloanthracyclines

C Demetzos  1 , A L Skaltsounis, S Michel, F Tillequin, M Koch, M Anstett, S Leonce, A Pierré, G Atassi
Affiliations
  • PMID: 8166928

Synthesis and biological activity of 3'-deamino-3'-haloanthracyclines

C Demetzos et al. Anticancer Drug Des. 1994 Apr.

Abstract

4'-O-Acetyl-3'-deamino-3'-chloro and 4'-O-acetyl-3'-deamino-3'-bromoepidaunorubicin analogs have been synthesized by condensation of daunomycinone with the corresponding hexopyranosyl chlorides. The glycosides obtained were less potent than adriamycin (ADR) in inhibiting the proliferation of tumor cells in vitro, but they have shown promising activity against a variety of multidrug resistant (MDR) cell lines.

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