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Comparative Study
. 1994 Apr 28;1221(3):353-6.
doi: 10.1016/0167-4889(94)90261-5.

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

E Araki  1 , B L Haag 3rd, C R Kahn
Affiliations
Comparative Study

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

E Araki et al. Biochim Biophys Acta. .

Abstract

The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.

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