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. 1993 Oct;79(10):39-45.

[The effect of acetylcholine on neuromuscular transmission in the fatigued rat diaphragm with blocked acetylcholinesterase]

[Article in Russian]
I V Kubasov, I I Krivoĭ
  • PMID: 8167666

[The effect of acetylcholine on neuromuscular transmission in the fatigued rat diaphragm with blocked acetylcholinesterase]

[Article in Russian]
I V Kubasov et al. Fiziol Zh Im I M Sechenova. 1993 Oct.

Abstract

The rat phrenic-diaphragm preparations with amine-inhibited acetylcholinesterase were fatigued by rhythmical nerve stimulation. Tetanization of the nerve by bursts of stimuli 20/sec led to a long-term recovery of muscle contractions of the fatigued muscles. The recovery was completely abolished by tubocurarine and partially--by atropine. Acetylcholine bathing simulated the effect of tetanization. Probable mechanisms of this phenomenon are discussed.

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