Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 May;176(9):2754-8.
doi: 10.1128/jb.176.9.2754-2758.1994.

Guanine nucleotide-dependent assembly of FtsZ into filaments

A Mukherjee  1 , J Lutkenhaus
Affiliations
Comparative Study

Guanine nucleotide-dependent assembly of FtsZ into filaments

A Mukherjee et al. J Bacteriol. 1994 May.

Abstract

FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP binding site. Examination of FtsZ incubated in vitro by electron microscopy revealed a guanine nucleotide-dependent assembly into protein filaments, supporting the hypothesis that the FtsZ ring is formed through self-assembly. FtsZ3, which is unable to bind GTP, does not polymerize, whereas FtsZ2, which binds GTP but is deficient in GTP hydrolysis, is capable of polymerization.

PubMed Disclaimer

References

    1. J Mol Biol. 1992 Sep 5;227(1):307-21 - PubMed
    1. J Bacteriol. 1994 Jan;176(1):130-6 - PubMed
    1. Nature. 1992 Sep 17;359(6392):254-6 - PubMed
    1. Eur J Biochem. 1992 Nov 15;210(1):343-9 - PubMed
    1. J Biol Chem. 1993 Jan 5;268(1):127-32 - PubMed

Publication types

MeSH terms

LinkOut - more resources