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Comparative Study
. 1994 Apr 26;91(9):3505-9.
doi: 10.1073/pnas.91.9.3505.

Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart

M Biel  1 , X Zong, M Distler, E Bosse, N Klugbauer, M Murakami, V Flockerzi, F Hofmann
Affiliations
Comparative Study

Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart

M Biel et al. Proc Natl Acad Sci U S A. .

Abstract

Cyclic nucleotide-gated cation channels are essential in visual and olfactory signal transduction. An additional member of the cGMP-gated channel family, termed CNG-3, has been cloned from bovine kidney. Its deduced amino acid sequence is 60% and 62% identical with the CNG-channel proteins from bovine rod outer segment and bovine olfactory epithelium, respectively. Northern analysis and sequences amplified by the PCR showed that the CNG-3 mRNA is present in testis, kidney, and heart. Calcium permeated the expressed channel in the presence of extracellular Mg2+ and Na+ at membrane potentials from -100 to +45 mV. It is likely that CNG-3 protein is responsible for cGMP-induced Ca2+ entry in cells other than sensory cells.

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