Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Apr 26;91(9):4062-6.
doi: 10.1073/pnas.91.9.4062.

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice

C G Drake  1 , S K Babcock, E Palmer, B L Kotzin
Affiliations

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice

C G Drake et al. Proc Natl Acad Sci U S A. .

Abstract

Lupus-like autoimmunity in (NZB x NZW)F1 mice is frequently marked by the development of a severe and fatal renal disease. Genes from both NZB and NZW parents are required for the full expression of disease. We applied a mapping technique based on polymorphism in simple sequence repeats to the analysis of (NZB x NZW)F1 x NZW backcross mice to determine the NZB genetic contribution to disease. The results show that a single NZB locus or tightly linked group of loci on the distal part of chromosome 4 provides the strongest association with renal disease and death. This locus, designated here as nba-1 (New Zealand Black autoimmunity), lies distal to the locus elp-1, 60-70 centimorgans from the centromere. It is of interest that a gene encoding a receptor for tumor necrosis factor maps to the vicinity of this disease-associated gene.

PubMed Disclaimer

References

    1. Clin Immunol Immunopathol. 1989 Sep;52(3):421-34 - PubMed
    1. Science. 1993 Jul 16;261(5119):345-8 - PubMed
    1. Science. 1990 May 25;248(4958):1019-23 - PubMed
    1. J Exp Med. 1990 Jun 1;171(6):2141-6 - PubMed
    1. Adv Immunol. 1968;9:215-66 - PubMed

Publication types