A lymphotoxin-beta-specific receptor
- PMID: 8171323
- DOI: 10.1126/science.8171323
A lymphotoxin-beta-specific receptor
Abstract
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.
Comment on
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Unraveling function in the TNF ligand and receptor families.Science. 1994 Apr 29;264(5159):667-8. doi: 10.1126/science.8171316. Science. 1994. PMID: 8171316 No abstract available.
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