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Comment
. 1994 Apr 29;264(5159):707-10.
doi: 10.1126/science.8171323.

A lymphotoxin-beta-specific receptor

P D Crowe  1 , T L VanArsdale, B N Walter, C F Ware, C Hession, B Ehrenfels, J L Browning, W S Din, R G Goodwin, C A Smith
Affiliations
Comment

A lymphotoxin-beta-specific receptor

P D Crowe et al. Science. .

Abstract

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.

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