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Case Reports
. 1994:5 Suppl 1:43-5.
doi: 10.1093/annonc/5.suppl_1.s43.

Quantitation of follicular non-Hodgkin's lymphoma cells carrying t(14;18) in a patient before and after allogeneic bone marrow transplantation

J P Meijerink  1 , G J Goverde, T F Smetsers, J M Raemaekers, M J Bogman, T de Witte, E J Mensink
Affiliations
Case Reports

Quantitation of follicular non-Hodgkin's lymphoma cells carrying t(14;18) in a patient before and after allogeneic bone marrow transplantation

J P Meijerink et al. Ann Oncol. 1994.

Abstract

Background: A competitive PCR method was developed, enabling accurate quantitation of residual lymphoma cells carrying the t(14;18) in blood and bone marrow samples of follicular non-Hodgkin's lymphoma (NHL) patients during treatment.

Patients and methods: A patient with residual lymphoma cells received an allogeneic bone marrow transplantation (BMT). Since BMT, the patient has been in continuing clinical complete remission.

Results: Using the competitive PCR and two-step PCR method, we were able to demonstrate a gradual decline in the number of lymphoma cells within consecutive patient blood and bone marrow samples after BMT.

Conclusions: The competitive PCR is a suitable method for the detection of minimal residual disease. Further research might reveal the clinical relevance of data obtained by this method.

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