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. 1994 May;163(1):11-8.
doi: 10.1006/dbio.1994.1119.

Repeated sequence target sites for maternal DNA-binding proteins in genes activated in early sea urchin development

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Repeated sequence target sites for maternal DNA-binding proteins in genes activated in early sea urchin development

R Anderson et al. Dev Biol. 1994 May.

Abstract

This communication concerns a very highly conserved inverted repeat sequence element that serves as a target site for a sea urchin maternal DNA-binding factor. The maternal factor is present in relatively large amounts in unfertilized eggs, but is about 100 x less prevalent per embryo in 24-hr embryo nuclear extract. The inverted repeat target site is found in the regulatory domain of the CyIIIa cytoskeletal actin gene and also in two upstream genes encoding transcription factors that bind to a functionally important cis-regulatory element of the CyIIIa gene. There are about 460 copies of the inverted repeat target site per genome. About 15% of these sites occur in a nested arrangement together with a second inverted repeat that binds another previously characterized maternal transcription factor. This arrangement is the same as that which occurs in the CyIIIa gene, and it may be of regulatory significance with respect to activation of certain genes in oogenesis and early embryogenesis.

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