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. 1994 Feb 14;167(1-2):125-7.
doi: 10.1016/0304-3940(94)91043-x.

Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line

W Araki  1 , T Kunishita, K Takahashi, S Ikeda, T Tabira
Affiliations

Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line

W Araki et al. Neurosci Lett. .

Erratum in

  • Neurosci Lett 1994 Apr 25;171(1-2):225

Abstract

We investigated the secretion of amyloid beta-protein (beta AP) in a mouse neuronal cell line SN49. SN49 cells stably transfected with mouse beta-amyloid precursor protein (APP) 695 cDNA released approximately three times greater amounts of a 4 kDa protein immunoreactive with anti-beta AP antibodies than untransfected and mock-transfected cells. This 4 kDa protein was further identified as mouse beta AP by direct amino acid sequence analysis. These results strongly suggest that the beta AP secretion occurs in mouse neuronal cells as in human cells.

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