doi: 10.1126/science.8178172.
Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF
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- PMID: 8178172
- DOI: 10.1126/science.8178172
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Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF
Science.
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Abstract
Xenopus UBF (xUBF) interacts with DNA by way of multiple HMG-box domains. When xUBF binds to the ribosomal promoter, the carboxyl-terminal acidic tail and amino-terminal HMG-box interact. Binding also leads to negative DNA supercoiling and the formation of a disk-like structure, the enhancesome. Within the enhancesome, an xUBF dimer makes a low-density protein core around which DNA is looped into a single 180-base pair turn, probably by in-phase bending. The enhancesome structure suggests a mechanism for xUBF-dependent recruitment of the TATA box-binding protein complex without direct interaction between the two factors.
Comment in
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Architectural transcription factors.Science. 1994 May 20;264(5162):1100-1. doi: 10.1126/science.8178167. Science. 1994. PMID: 8178167 Review. No abstract available.
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