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. 1994 May 20;264(5162):1141-5.
doi: 10.1126/science.8178173.

Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

J Tomfohrde  1 , A Silverman, R Barnes, M A Fernandez-Vina, M Young, D Lory, L Morris, K D Wuepper, P Stastny, A Menter, et al.
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Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q

J Tomfohrde et al. Science. .

Abstract

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

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