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Case Reports
. 1994 May;35(5):616-9.
doi: 10.1002/ana.410350516.

Parkinsonism induced by solvent abuse

R J Uitti  1 , B J Snow, H Shinotoh, F J Vingerhoets, M Hayward, S Hashimoto, J Richmond, S P Markey, C J Markey, D B Calne
Affiliations
Case Reports

Parkinsonism induced by solvent abuse

R J Uitti et al. Ann Neurol. 1994 May.

Abstract

We report the first description of a patient with parkinsonism induced by solvent abuse. Our patient developed parkinsonism acutely, following heavy abuse of lacquer thinner. Her clinical deficits were indistinguishable from idiopathic parkinsonism (Parkinson's disease) and she responded to levodopa. Parkinsonism has persisted for more than 3 months. Brain computed tomography was normal. Positron emission tomographic studies showed normal fluorodopa uptake and reduced raclopride binding, indicating an unusual disturbance of striatal dopaminergic function. This patient suggests that organic solvents may cause parkinsonism in susceptible individuals.

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