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. 1993 Dec 1;248(4):333-5.
doi: 10.1016/0926-6917(93)90009-f.

Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior

M D Aceto  1 , S M Scates, Z Ji, E R Bowman
Affiliations

Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior

M D Aceto et al. Eur J Pharmacol. .

Abstract

Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significantly promotes and maintains smoking behavior.

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