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. 1994 May;55(5):658-61.
doi: 10.1002/jlb.55.5.658.

Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development

J W Armstrong  1 , S J Simske, A A Beharka, S Balch, M W Luttges, S K Chapes
Collaborators, Affiliations

Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development

J W Armstrong et al. J Leukoc Biol. 1994 May.

Abstract

Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.

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