Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Feb;31(2):126-9.
doi: 10.1136/jmg.31.2.126.

Facial clefts in the west of Scotland in the period 1980-1984: epidemiology and genetic diagnoses

D R FitzPatrick  1 , P A Raine, J G Boorman
Affiliations

Facial clefts in the west of Scotland in the period 1980-1984: epidemiology and genetic diagnoses

D R FitzPatrick et al. J Med Genet. 1994 Feb.

Abstract

Two hundred and eighty six cases of cleft lip, cleft palate, or both were identified in a study attempting complete ascertainment of babies with facial clefts born to women resident in the west of Scotland in a five year period beginning 1 January 1980. The total birth prevalence (TBP) of these defects over this period was 1.53 per 1000. The TBP for cleft lip with or without cleft palate (CL[P] was 0.74 per 1000 and for cleft palate (CP) was 0.79 per 1000; 26% of CL[P] and 39.5% of CP cases had one or more major congenital anomaly associated with their facial cleft and in over half of these cases a specific genetic or syndrome diagnosis could be made. In comparison to previous European reports this study shows a high incidence of associated abnormalities and a remarkably low ratio of CL[P]:CP cases.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1989 Sep;45(3):348-53 - PubMed
    1. J Med Genet. 1982 Feb;19(1):8-15 - PubMed
    1. Arch Dis Child. 1963 Feb;38:66-70 - PubMed
    1. Plast Reconstr Surg. 1965 May;35:548-51 - PubMed
    1. Am J Hum Genet. 1970 May;22(3):336-52 - PubMed