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. 1976 Jun 1;143(6):1352-66.
doi: 10.1084/jem.143.6.1352.

Nonspecific complement activation by streptococcal structures. II. Properdin-independent initiation of the alternate pathway

J W Tauber, M J Polley, J B Zabriskie

Nonspecific complement activation by streptococcal structures. II. Properdin-independent initiation of the alternate pathway

J W Tauber et al. J Exp Med. .

Abstract

Complement consumption by isolated membranes and walls from Group A streptococci and various other gram-positive microbes has been tested. These microbial structures were found to activate the alternate complement pathway. However, unlike endotoxin, inulin, or other plant polysaccharides, activation of complement by our material was found to bypass properdin. The activating factor(s) also differs from cobra venom in its/their requirement for factor D. Preliminary experiments suggest this factor isolated from membranes to be a protein and to have a mol wt greater than 40-60,000 daltons. Our studies have led us to speculate that the phylogenetic role of the alternate complement pathway may be the primordial nonspecific defense system which has retained certain fundamental aspects up to the present time.

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References

    1. J Exp Med. 1959 Dec 1;110:853-74 - PubMed
    1. J Bacteriol. 1964 Oct;88:1198-200 - PubMed
    1. J Biol Chem. 1957 May;226(1):497-509 - PubMed
    1. J Exp Med. 1956 Aug 1;104(2):217-31 - PubMed
    1. J Immunol. 1953 Nov;71(5):339-45 - PubMed

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