Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 May 26;369(6478):289-94.
doi: 10.1038/369289a0.

Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit

J Rettig  1 , S H Heinemann, F Wunder, C Lorra, D N Parcej, J O Dolly, O Pongs
Affiliations

Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit

J Rettig et al. Nature. .

Abstract

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.

PubMed Disclaimer

Publication types

Substances

Associated data

LinkOut - more resources