[Potential for using kappa-carrageenan for characterization of cell functional status in the system of mononuclear phagocytes in cytostatic disease]

Abstract

Intraperitoneal administration of doxorubicin in the maximum tolerable dose of 6 mg/kg to CBA mice reduces the release of colloidal charcoal from the blood bed, lowers the levels of peritoneal macrophages, results in monocytopenia and a short-term moderate inhibition of monocytopoiesis. kappa-Carrageenan given in an intraperitoneal dose of 5 mg/kg 24 hours after the antitumor antibiotic leads to cell accumulation in the system of mononuclear phagocytes in the abdomen wherein they phagocytes carrageenan, to stimulation of monocytopoiesis. Intraperitoneal polygalactan causes a long-term (25-day) cell block in the mononuclear phagocyte system primarily in the abdomen, as well as in the liver, bone marrow, and spleen, reducing, to a greater extent, the clearing activity of mononuclear phagocytes in mice pretreated with the cytostatic.