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Comparative Study
. 1994 May 10;91(10):4298-302.
doi: 10.1073/pnas.91.10.4298.

Codon reiteration and the evolution of proteins

H Green  1 , N Wang
Affiliations
Comparative Study

Codon reiteration and the evolution of proteins

H Green et al. Proc Natl Acad Sci U S A. .

Abstract

Sequence data banks have been searched for proteins possessing uninterrupted reiterations of any amino acid. Hydrophilic amino acids, and particularly glutamine, account for a large proportion of the longer reiterants. In the genes for these proteins, the most common reiterants are those that contain poly(CAG), even out-of-frame or, to a lesser degree, those that contain repeated doublets of CA, AG, or GC. The preferential generation of such reiterants requires that DNA strand-specific signals predispose to reiteration and thus to the extension of coding regions.

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