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Clinical Trial
. 1976 Jul 31;2(6030):272-3.
doi: 10.1136/bmj.2.6030.272.

Comparison of atenolol and propranolol during insulin-induced hypoglycaemia

S P Deacon, D Barnett
Clinical Trial

Comparison of atenolol and propranolol during insulin-induced hypoglycaemia

S P Deacon et al. Br Med J. .

Abstract

The effects of atenolol, a new beta1-blocking drug, on pulse rate, sweating, and blood glucose levels during insulin-induced hypoglycaemia were studied in a double-blind crossover trial in eight normal subjects using placebo and propranolol as reference agents. The intensity of induced hypoglycaemia was identical for atenolol, propranolol, and placebo. Propranolol prolonged hypoglycaemia, but atenolol did not. Atenolol may therefore be safe for use in patients receiving insulin.

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