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. 1976 May 28;192(4242):892-4.
doi: 10.1126/science.818706.

Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats

A J Matas, D E Sutherland, M W Steffes, S M Mauer, A Sowe, R L Simmons, J S Najarian

Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats

A J Matas et al. Science. .

Abstract

A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme uridine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.

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