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Review
. 1994 May 16;344(2-3):105-8.
doi: 10.1016/0014-5793(94)00320-3.

Regulatory squelching

M A Cahill  1 , W H Ernst, R Janknecht, A Nordheim
Affiliations
Free article
Review

Regulatory squelching

M A Cahill et al. FEBS Lett. .
Free article

Abstract

An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.

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