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Comparative Study
. 1994 May;176(10):3072-5.
doi: 10.1128/jb.176.10.3072-3075.1994.

gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi

D S Samuels  1 , R T Marconi, W M Huang, C F Garon
Affiliations
Comparative Study

gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi

D S Samuels et al. J Bacteriol. 1994 May.

Abstract

We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.

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