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Review
. 1994;120(7):427-33.
doi: 10.1007/BF01240143.

Limited-sampling models for anticancer agents

L J van Warmerdam  1 , W W ten Bokkel Huinink, R A Maes, J H Beijnen
Affiliations
Review

Limited-sampling models for anticancer agents

L J van Warmerdam et al. J Cancer Res Clin Oncol. 1994.

Abstract

Pharmacokinetic parameters of antineoplastic drugs are usually generated from concentration/time profiles obtained after multiple venipunctures. With limited-sampling models (LSM) this number can be reduced to between one and three timed plasma samples. LSMs may facilitate population pharmacokinetic/pharmacodynamic studies, which eventually may lead to a dosing strategy based on the characteristics of the individual patient. In this article, the development, validation and application of several LSMs reported in the literature are reviewed.

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