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Clinical Trial
. 1994 Jun;30(6):977-81.
doi: 10.1016/s0190-9622(94)70121-0.

Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients

P J Altmeyer  1 , U Matthes, F Pawlak, K Hoffmann, P J Frosch, P Ruppert, S W Wassilew, T Horn, H W Kreysel, G Lutz, et al.
Affiliations
Clinical Trial

Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients

P J Altmeyer et al. J Am Acad Dermatol. 1994 Jun.

Abstract

Background: Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret.

Objective: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.

Methods: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.

Results: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.

Conclusion: Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.

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