Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Jun;68(6):4092-6.
doi: 10.1128/JVI.68.6.4092-4096.1994.

The influenza virus panhandle is involved in the initiation of transcription

E Fodor  1 , D C Pritlove, G G Brownlee
Affiliations

The influenza virus panhandle is involved in the initiation of transcription

E Fodor et al. J Virol. 1994 Jun.

Abstract

The role of the influenza A virus panhandle structure formed from the 3'- and 5'-terminal nucleotides of virion RNA segments was studied in both an RNA polymerase binding assay and an in vitro transcription assay. Despite recent indications that promoter activity is simply a function of the 3'-terminal sequence of virion RNA, our results show that both 3'- and 5'-terminal sequences are involved in the initiation of transcription. We propose a new model for the initiation of transcription which has implications for the mechanisms by which influenza virus transcription, replication, and polyadenylation may be regulated in the infected cell.

PubMed Disclaimer

References

    1. Nat New Biol. 1973 Nov 14;246(150):40-1 - PubMed
    1. J Virol. 1994 Mar;68(3):1509-15 - PubMed
    1. Nucleic Acids Res. 1979 Aug 24;6(12):3745-57 - PubMed
    1. Cell. 1979 Oct;18(2):329-34 - PubMed
    1. Gene. 1980 Feb;8(3):315-28 - PubMed

Publication types

LinkOut - more resources