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. 1994 Feb;89(2):95-101.
doi: 10.1111/j.1600-0404.1994.tb01642.x.

Effect of high-dose steroid therapy on T-cell subpopulations. A longitudinal study in MS patients

P Gallo  1 , M Chiusole, M Sanzari, S Sivieri, M G Piccinno, V Argentiero, P Rizzotti, B Tavolato
Affiliations

Effect of high-dose steroid therapy on T-cell subpopulations. A longitudinal study in MS patients

P Gallo et al. Acta Neurol Scand. 1994 Feb.

Abstract

Lymphocyte subpopulations, T cell activation antigens, and serum levels of interleukin 2 (IL-2) and soluble IL-2 receptor (sIL2R), were studied in relapsing-remitting MS (RR-MS) patients before and after high-dose steroid therapy. Prior to therapy, a minority of patients showed increased HLA-DR antigen expression, and an increased number of CD16+ and CD19+ cells. Steroid treatment induced a significant increase in HLA-DR and CD19 expression, a significant reduction in CD16+, CD57+, and CD8+ CD57+ cells, and a slight, non-significant, decrease in IL-2 and sIL-2R levels and CD25 expression on CD4+ T lymphocytes.

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