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Comparative Study
. 1994 Feb;38(2):392-5.
doi: 10.1128/AAC.38.2.392.

Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

C Urban  1 , K S Meyer, N Mariano, J J Rahal, R Flamm, B A Rasmussen, K Bush
Affiliations
Comparative Study

Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae

C Urban et al. Antimicrob Agents Chemother. 1994 Feb.

Abstract

An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme with an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large transferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.

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References

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