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. 1994 Feb;160(2):97-103.

Experimental evaluation of oxygen free radical scavengers in the prevention of reperfusion injury in skeletal muscle

S Oredsson  1 , G Plate, P Qvarfordt
Affiliations
  • PMID: 8193214

Experimental evaluation of oxygen free radical scavengers in the prevention of reperfusion injury in skeletal muscle

S Oredsson et al. Eur J Surg. 1994 Feb.

Abstract

Objective: To evaluate the role of oxygen-derived free radicals in reperfusion injury of skeletal muscle in rabbits.

Design: Open experimental study.

Setting: Department of experimental surgery.

Material: 32 rabbits.

Interventions: Four groups according to pretreatment: group I: superoxide dismutase-superoxide scavenger; group II: catalase-hydrogen peroxide scavenger; group III: superoxide dismutase and catalase; group IV: mannitol-hydroxyl scavenger. Amputated hindlimbs were subjected to 4 hours of ischaemia followed by 2 hours of reperfusion. One limb was treated while the other served as a control.

Main outcome measures: Muscle water content, energy charge, and muscle injury (uptake of 99mTc-methylenediphosphonate).

Results: Muscle water content was reduced in group III (p < 0.05) and IV (p < 0.05). Energy charge was improved in group IV (p < 0.05). Muscle injury was reduced in groups II (p < 0.05), III (p < 0.05), and IV (p < 0.01), but most in group IV (p < 0.01).

Conclusion: Oxygen-derived free radicals seem to be mediators in reperfusion injury of skeletal muscle. The hydroxyl radical seems to be the most important of the xanthine oxidase-derived free radicals.

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