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. 1994 Apr;21(4):281-3.
doi: 10.1111/j.1600-051x.1994.tb00318.x.

Amlodipine-induced gingival overgrowth

R A Seymour  1 , J S Ellis, J M Thomason, S Monkman, J R Idle
Affiliations

Amlodipine-induced gingival overgrowth

R A Seymour et al. J Clin Periodontol. 1994 Apr.

Abstract

Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.

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