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. 1994 May 24;91(11):5075-9.
doi: 10.1073/pnas.91.11.5075.

Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody

L Duan  1 , O Bagasra, M A Laughlin, J W Oakes, R J Pomerantz
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Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody

L Duan et al. Proc Natl Acad Sci U S A. .

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Abstract

Human immunodeficiency virus type 1 (HIV-1) has a complex life cycle, which has made it a difficult target for conventional therapeutic modalities. A single-chain antibody moiety, directed against the HIV-1 regulatory protein Rev, which rescues unspliced viral RNA from the nucleus of infected cells, has now been developed. This anti-Rev single-chain construct (SFv) consists of both light and heavy chain variable regions of anti-Rev monoclonal antibody, which, when expressed intracellularly within human cells, potently inhibits HIV-1 replication. This intracellular SFv molecule is demonstrated to specifically antagonize Rev function. Thus, intracellular SFv expression, against a retroviral regulatory protein, may be useful as a gene therapeutic approach to combat HIV-1 infections.

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