Review
doi: 10.1016/0047-6374(75)90033-0.
Aging and the alteration of enzymes: a review
- PMID: 819726
- DOI: 10.1016/0047-6374(75)90033-0
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Review
Aging and the alteration of enzymes: a review
Mech Ageing Dev.
1975 Sep-Dec.
Abstract
The present status of research on age-related alterations of enzymes is reviewed. Evidence which makes it clear that "altered" enzymes do, in fact, exist in old animals is presented. The alteration may result from either a sequence change or a post-synthetic modification. The "error hypothesis" would support the former mechanism; a proposal based upon increasing half-lives of proteins with age could explain the latter. Evidence supporting or contradicting these alternatives is discussed.
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