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Comparative Study
. 1978 Nov 4;2(8097):966-8.
doi: 10.1016/s0140-6736(78)92529-1.

Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan

D W Hedley, T J McElwain, J L Millar, M Y Gordon
Comparative Study

Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan

D W Hedley et al. Lancet. .

Abstract

7 patients with advanced malignant melanoma who were given cyclophosphamide (500 mg intravenously) 7 days before a high dose of melphalan (140 mg/m2) had a more rapid recovery of the peripheral white-cell count than did 4 patients who received melphalan alone. "Priming" by cyclophosphamide might be a practicable means of offsetting the bone-marrow toxicity of some chemotherapy regimens and it may permit higher doses of drugs to be given safely.

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