doi: 10.1111/j.1365-2141.1994.tb04764.x.
Evaluation of mixed chimaerism and origin of bone marrow derived fibroblastoid cells after allogeneic bone marrow transplantation
Affiliations
- PMID: 8199044
- DOI: 10.1111/j.1365-2141.1994.tb04764.x
Item in Clipboard
Evaluation of mixed chimaerism and origin of bone marrow derived fibroblastoid cells after allogeneic bone marrow transplantation
Br J Haematol.
1994 Feb.
Abstract
We assessed the origin of bone marrow derived fibroblastoid cells (BMF) in long-term cultures of 13 samples obtained from nine patients after allo-BMT by polymerase chain reaction (PCR) amplification of MCT118, one of the variable number of tandem repeats regions (VNTR). BMF showed a complete recipient pattern in nine samples obtained from seven patients; however, a recipient-predominant mixed chimaeric pattern was detected in BMF from four patients. Also, two of the four patients died with bone marrow hypoplasia. These data suggest that mixed chimaeric pattern of BMF may be correlated with bone marrow hypoplasia.
Similar articles
-
Recipient origin of bone marrow-derived fibroblastic stromal cells during all periods following bone marrow transplantation in humans.Br J Haematol. 1991 Nov;79(3):359-65. doi: 10.1111/j.1365-2141.1991.tb08041.x. Br J Haematol. 1991. PMID: 1751363
-
Evaluation of mixed chimerism by two-step polymerase chain reaction amplification of hypervariable region MCT118 after allogeneic bone marrow transplantation.Ann Hematol. 1994 Apr;68(4):189-93. doi: 10.1007/BF01834365. Ann Hematol. 1994. PMID: 8003560
-
[Clinical application of gene technology to monitor bone marrow transplantation].Rinsho Byori. 1994 Mar;42(3):249-56. Rinsho Byori. 1994. PMID: 8152160 Japanese.
-
[Molecular study of bone marrow chimerism and expression of EVI-1 gene as manifestations of minimal residual disease after bone marrow transplantation (BMT)].Med Wieku Rozwoj. 1999 Jan-Mar;3(1):139-52. Med Wieku Rozwoj. 1999. PMID: 10910646 Review. Polish.
-
Mixed chimaerism; detection and significance following BMT.Bone Marrow Transplant. 1993 Feb;11(2):91-4. Bone Marrow Transplant. 1993. PMID: 8435668 Review.
Cited by
-
Immunological reconstitution and immunoregulatory cells in hematopoietic stem cell transplantation.Int J Hematol. 2002 Aug;76 Suppl 1:191-4. doi: 10.1007/BF03165243. Int J Hematol. 2002. PMID: 12430852 Review.
-
Mesenchymal stem cells in stem cell transplant recipients are damaged and remain of host origin.Int J Hematol. 2005 Aug;82(2):152-8. doi: 10.1532/IJH97.A10505. Int J Hematol. 2005. PMID: 16146849
-
Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1142-7. doi: 10.1073/pnas.95.3.1142. Proc Natl Acad Sci U S A. 1998. PMID: 9448299 Free PMC article.
-
A Systematic Review of the Evidence of Hematopoietic Stem Cell Differentiation to Fibroblasts.Biomedicines. 2022 Nov 28;10(12):3063. doi: 10.3390/biomedicines10123063. Biomedicines. 2022. PMID: 36551819 Free PMC article. Review.
-
Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia.Exp Hematol. 2009 Dec;37(12):1464-71. doi: 10.1016/j.exphem.2009.09.008. Epub 2009 Sep 26. Exp Hematol. 2009. PMID: 19786066 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
